Allan herndon dudley syndrome is an uncommon disorder of mind growth that causes conservative to serious psychological retardation and problems with campaign. This circumstance, which occurs solely in males, disrupts growth from before birth.
Allan herndon dudley syndrome may be characterized by serious psychological retardation, a diminished power to organize words and talk understandably (dysarthria), diminished muscle color, and campaign abnormalities. This circumstance, which occurs solely in males, disrupts growth from before birth. As an outcome, many folk with Allan herndon dudley syndrome are incapable to walk independently and get wheelchair-bound by maturity.
Most children with Allan herndon dudley syndrome have feeble muscle color and underdevelopment of many muscles. As they go old, they normally produce multilateral deformities called contractures, which limit the campaign of sure joints. Abnormal muscle awkwardness, muscle failing, and forced movements of the weaponry and legs too restrict mobility. In males (who have simply one X chromosome), one altered transcript of the gene in each cubicle is adequate to induce the circumstance. In females (who have two X chromosomes), a variation must be existing in both copies of the gene to induce the disorder. A dramatic feature of X-linked heritage is that fathers cannot passing X-linked traits to their sons.
A physical examination, medical history, and numerous tests can aid in diagnosis. Associated features often include underdevelopment and wasting of muscle tissue; weakness and stiffness of the legs with exaggerated reflexes, relatively slow, involuntary, purposeless, writhing movements (athetoid movements); and other movement abnormalities. Allan herndon syndrome is thought to be inherited as an X-linked recessive trait and therefore is typically fully expressed in males only. There is no cure for Allan herndon dudley syndrome nor is there any specific treatment. Treatment is highly individualized. Because patients are usually severely cognitively impaired, special education and structured care is needed. Physical therapy appears to help with some movement problems.
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