Medicines and Drugs to Treat Peptic Ulcers
What is an ulcer?
Colloidal Bismuth or Tripotassium Dicitrato Bismuthate TDB (Trymo, Denol)
This is also used for the same purpose as sucralfate. The dose is 240 mg, twice daily, half an hour before meals. It causes blackening of the stools and tongue, dizzines diarrhoea and bismuth toxicity. It detaches H pylori and kills them. So it is used in eradication regime also.
Eradication of H. Pylori Infection in Peptic Ulcer
H-pylori is responsible for causing chronic gastritis, dyspepsia, peptic ulcer and stomach tumor in many cases 90% cases of gastric and duodenal ulcers have H. pylori in their stomachs. Eradication of this organism is difficult with single drug. Therefore a combination of two or three drugs is used.
It is a very common problem presenting as sour eructations, heartburn and water brash. The symptoms occur particularly after a large meal and increase on lying down. In this disorder the acid contents of stomach rise in the lower part of food pipe (esophagus). The lower end of food pipe has a valve like mechanism to prevent reguritation of acid contents. When this valve (sphincter) becomes lax or weak, the acid burns the lining of food pipe causing erosions, ulcers and heartburns. In many cases of night-time attacks of asthma, reflux is found to be a common problem. If untreated the food pipe is ultimately narrowed not allowing hard food to pass down (dysphagia). There is a risk of cancer development. Therefore, it should be treated vigorously.
Dosage: Omeprazole 20 mg, twice a day or lansoprazole 15 to 30 mg, daily for 4 to 8 week are better than H2 blockers (ranitidine or famotidine). These are often combined with prokinetic drugs. Common formulations are Omidom, Domstal-O (Omeprazole + Domperidone), Pentadom (Pantoprazole + Domperidone) and Zerocid (Lansoprazole + Domperidone).
Precautions: Persons suffering from reflux esophagitis should take light early dinner. The foot end of the bed should be raised to provide much relief. Weight reduction can also help.
It forms thick frothy layer on the gastric juice and thus prevents acid regurgitation. It is combined with antacids.
Source: Free Articles from ArticlesFactory.com
ABOUT THE AUTHOR
AdvCare is one of the Canada leading pharmacy website. First established in January 2000, its mission is to become the number one site for prescription drug and drug store searches.