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Great Plains integrations, especially in Edi and ecommerce scenarios are very popular and in our opinion they are not overly too complex to design and implement.  If you are MS Visual Studio C#, VB .Net programmer with some SQL and XML skills, you should be able to program real time or batch mode integrations in eConnect SDK for Dynamics GP, and as such your integration could be called directly as part of your ecommerce web site instruments.