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Using natural progesterone and osteoporosis was successfully treated? Is it possible? After all, natural progesterone is safe with virtually no side effects when used correctly. It is one of the two primary hormones produced in a healthy woman during the menstrual cycle, the other hormone being estrogen. In perhaps the only study of natural progesterone and osteoporosis treatment of its kind, the success obtained by a leading Harvard-trained physician for reversing osteoporosis in women is explained.