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Smallpox, a highly contagious disease, is unique only to humans. The smallpox virus is caused by two virus variants called Variola major and Variola minor. Variola major is the more deadly form of the virus; it usually has a mortality rte of 20-40 percent of those that are infected with the virus. Variola minor on the other hand is much less severe and only kills 1% of its victims. Neither of the Variola's are bugs that you want to get. Avoid them at all costs!