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Serotonin, norepinephrine and dopamine are all chemicals that are involved in regulating mood, energy, motivation, appetite and sleep.  In addition, the frontal lobe of the brain, which is important in controlling mood, is known to be under active in people with Parkinson's.  It's no wonder that Parkinson's patients may look sad.  We have every right -our brain is messed up. But looking sad and feeling sad are two different things.