Nov 1 09:01 2010 Rakesh Mishra Print This Article

Depression medication can help a person who is dealing with a depressive disorder. Doctors have access to many different drugs, but they all fall into three main categories.

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Depression medication can help a person who is dealing with a depressive disorder. Doctors have access to many different drugs, but they all fall into three main categories.


Nortriptyline is a second-generation tricyclic antidepressant (TCA) marketed as the hydrochloride salt under the trade names Sensoval, Aventyl, Pamelor, Norpress, Allegron, Noritren and Nortrilen. It is used in the treatment of major depression and childhood nocturnal enuresis (bedwetting). In addition, it is sometimes used for chronic illnesses such as chronic fatigue syndrome, chronic pain and migraines, and labile affect in some neurological conditions


Nortriptyline is the active metabolite of amitriptyline that is demethylated in the liver. It inhibits the reuptake of norepinephrine (noradrenaline) and, to a lesser extent, serotonin with negligible effects on dopamine reuptake. Nortriptyline also has antagonistic effects at a variety of receptors:


These effects account for some therapeutic actions as well as for most side effects (sedation, hypotension, anticholinergic effects, etc.). Nortriptyline may also have a sleep-improving effect due to its affinity for 5HT2A and histaminergic receptors.[2] In the short run however, nortriptyline may disturb sleep due to its activating effect.


Like other tricyclic antidepressants, nortriptyline also blocks sodium channels, possibly accounting in part for its analgesic action.


Nortriptyline is FDA-approved for the treatment of major depression. In the United Kingdom, it may also be used for treating nocturnal enuresis, with courses of treatment lasting no more than three months. It is also used off-label for the treatment of panic disorder, irritable bowel syndrome, migraine prophylaxis and chronic pain or neuralgia modification (particularly TMJ disorder). It can also aid in quitting smoking, with one study showing a six-month abstinence rate of 14% for subjects receiving nortriptyline compared to 3% for subjects not undergoing pharmacological treatment. Research has been done suggesting it can reduce symptoms of ADHD.


For depression: Low starting doses are used, increasing as necessary to 75–100 mg (0–50 mg for adolescents and the elderly). Maximum daily dosage is 150 mg.[7]


For the management of nocturnal enuresis: lower dosages are used with the maximum period of treatment, including gradual withdrawal, being three months and a full examination including electrocardiogram (ECG or EKG) required before further courses.[7]


For its off-label use for migraine and headache prophylaxis and treating chronic pain: Treatment is started at very low 10 mg once at night to minimize side-effects. The dose is then increased every two weeks if required to a maximum of 150 mg. Nortriptyline is effective for treating migraine-associated vertigo in the same dose titration with 100 mg usually being the maximum necessary dose.


Dosage availability is 10mg, 25mg, 50mg, and 75mg capsules

For more information on Aventyl you can visit http://www.meds-hut.com/index.htm

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Rakesh Mishra
Rakesh Mishra

This is Jon from Indian SEO, you can check Meds Hut Website for Online foreign pharmacy

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