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We have recently seen a number of cases of iron deficiency anaemia, both in cats and dogs.
In iron deficiency, red cells do not develop the normal complement of iron–containing haemoglobin and the cells that form in the bone marrow are small (microcytic, low MCV) and hypochromic (low MCH and MCHC). The process of red cell maturation becomes prolonged so young red cells no longer contain large amounts of RNA and therefore do not appear polychromatic. As a result the anaemia is non- regenerative, with inappropropriately low reticulocyte counts. There is often a marked increase in variation in red cell shape (poikilocytosis) and red cell fragments (schistocytes) are often seen, as above.
In cats, the red cells are often so small that platelets appear larger than red cells and this overlap in sizing can contribute to apparently very high platelet counts as some automated counters include some small red cells in the platelet count.
Iron deficiency anaemia reflects chronic external blood loss, either through the gut associated with bleeding tumours or ulcers or occasionally with severe flea burdens and parasitic blood loss.
Serum iron, iron panels (including serum iron, total iron binding capacity, transferrin and % saturation) and occasionally staining bone marrow for iron, can all be useful in investigating these cases in addition to a full blood count (which must include smear evaluation since not all cases have a low MCV and MCHC). Occult faecal blood testing, after a minimum of three days off all red meat, is useful to check for blood loss in cases where blood loss is not detectable grossly.
While most non-regenerative anaemias have a poorer outlook, iron deficiency responds excellently and quickly to treatment that is aimed at stopping the blood loss and providing oral iron supplementation. Our current crop of iron deficiency anaemia cases all appear to be doing well now that they are on treatment.
For more information on iron deficiency anaemia visit www.ctdslab.co.uk
Diagnosing pancreatic disease in Pets
The laboratory diagnosis of pancreatic disease in dogs and cats has taken has made some significant progress in the last few years. Exocrine pancreatic insufficiency (EPI) is now recognised in both dogs and cats and while most affected animals are young there are a number of older animals that are affected. The canine Trypsin-Like Immunoreactivity (TLI) test is both sensitive and specific for EPI and is assayed as part of the canine intestinal profile together with folate and cobalamin. Feline TLI has been shown similarly to be an excellent assay for EPI in cats, however this test is currently available only in the USA. As a result, we do not routinely include this test in the feline intestinal profile but we would recommend adding it for all cats with steathorreic faeces and for cats that are thin despite eating well where other causes have been ruled out.Thyroid illness in cats and dogs
Common clinical signs of ... in dogs include weight gain, ... reduced exercise ... and poor coat quality. However, the disease affects almost all body systems and as a result aPets get diabetes too
Just like humans pets can suffer from diabetes mellitus too. By a simple blood test, called ... thay can be ... and then under the care of your ... surgeon, often treated succe