Alex Dean

Alex Dean

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Alex Dean Free Articles

Remdesivir is effective in preventing and treating primate coronavirus pneumonia

Earlier this February, the news that Gilead's drug remdesivir, which is under study, has cured patients with coronavirus spread across the country. In a short time, Remdesivir, an antiviral drug targeting Ebola, became “People's Hope”. Currently, Phase III clinical trials of Remdesivir in treating Coronavirus Disease 2019 (COVID-19) are still underway, which draw the wide attention of the public.

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Steps and stages of new drug development

The research on innovative drugs is a complex research system, which involves high-tech and interdisciplinary knowledge in chemistry, biology, and computational information science. The research process is mainly divided into two parts: new drug discovery and new drug development.

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A brief guide to the control and treatment of diabetic kidney disease (DKD)

Diabetic kidney disease (DKD) refers to kidney damage caused by chronic hyperglycemia. Clinically, it is mainly characterized by continuous albuminuria and/or reduced glomerular filtration rate (GFR). According to reports, about 20% to 40% of diabetic patients worldwide have DKD, and the prevalence of DKD is on the rise. What’s worse, the current situation of DKD prevention and control has encountered a bottleneck as the treatment rate of DKD patients is not high: only 50.8% of patients with albuminuria and 49.0% of CKD patients received ACEI/ARB treatment.

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10 antibody drugs that will receive regulatory approval in the US and Europe by 2020 (II)

The following is a brief introduction to the remaining 10 antibody drugs in the report. Among them, the first 7 are for non-cancer indications, and the last 3 are for cancer indications.

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10 antibody drugs that will receive regulatory approval in the US and Europe by 2020 (I)

The Antibody Society published a report at the end of November 2019, which analyzed the drug development advances in the field of antibodies. According to the report, in 2020, 12 antibody drugs will receive regulatory approval in the US or EU. However, the two drugs in the report, enfortumab vedotin and trastuzumab deruxtecan, have already been approved by the US FDA in advance in mid-to-late December 2019. Both are ADC drugs.

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A brief guide to antitumor natural product molecule

Since the 1940s, humans have begun to use synthetic, small-molecule inhibitors to treat tumors. A series of drugs, such as alkylating agents, fluorouracil, methotrexate, cyclophosphamide, have been launched on the market. However, most of these molecules have large side effects.

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Chinese herbal medicine: Tangeretin and Icariin

There are many medicinal plants around us in nature. Many of them have been discovered by humans, and have brought great medical value. Today I will introduce two of these plants.

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What are the therapeutic implications of GPCR inhibitors?

This article will talks about the therapeutic implications of GPCR inhibitors.

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DNA-Encoded Library and Drug Discovery

The discovery of a novel drug generally involves multiple phases, among which a very important step is the identification of binding molecules to protein targets of pharmaceutical interest.

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The discovery of RIP1 kinase inhibitor GSK2982772 in innovative drug discovery

Receptor interacting protein 1 (RIP1) regulates cell necrosis and inflammation and plays an important role in human pathology, such as immune regulation and inflammatory diseases. Harris et al. reported early in early 2016 that an excellent benzoxazinone-based lead compound (GSK481) that inhibits RIP1 kinase was found in the DNA-coding compound library. After a year, they again wrote an article reporting the process of obtaining a clinical candidate compound (GSK2982772) by optimizing GSK481, which demonstrated superior properties.

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The clinical efficacy of BTK inhibitors in the treatment of CLL

Studies of BTK as a target have enjoyed substantial popularity among the researcher circle ever since its role in B-cell maturation as well as in mast cell activation through the high-affinity IgE receptor have been confirmed, which given rise to the development of a diverse array of BTK inhibitors.

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What Are the Major Immune Checkpoint Inhibitors Being Researched?

The past decade has witnessed an increasing prevalence of biological drug development targeted for the regulation of immune checkpoints. Across the globe, there are many pharmaceutical companies that are developing PD-1 or PD-L1 antibodies as drugs. These immune checkpoint drugs fall into two categories: one is the inhibitor represented by PD-1; the other is the agonist. The agonist is still in clinical research.

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Cancer Immunotherapy: A Collection of Latest Findings

This article is a collection of latest fidings on immunotherapy.

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Can cancer cells be starved to death?

This article provides a new perspective as to whether cancer can be eradicated by cutting off their energy supply.

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A brief history of prostate cancer treatment

This article talks about the treatment history of prostate cancer.

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