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Peptide Modifications: Linkers, Spacers and PEGylation

Biochempeg is a biotechnology-oriented company in Watertown, Massachusetts.It provides custom PEGylated conjugates and PEGylation services for peptides, and small molecules.PEGylation is the process of covalently attaching polyethylene glycol (PEG) polymer chains to peptides.

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Safety And Effectiveness Of First-line Antihypertensive Drug Classes

This article is edited by Sonia Li who from Huateng Pharma.

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ADCs Effectively Targets Surface Protein Of Neuroblastoma In Children

This artile shows us ADCs can effectively targets surface protein of neuroblastoma in children.

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Application of PEG In Click Chemistry

Click chemistry is a method for attaching a probe or substrate of interest to a specific biomolecule, a process called bioconjugation. The possibility of attaching fluorophores and other reporter molecules has made click chemistry a very powerful tool for identifying, locating, and characterizing both old and new biomolecules.

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Three Drugs Combined Can Reduce Mortality in COPD Patients

Once-daily treatment of patients with chronic obstructive pulmonary disease (COPD) with an inhaler combining fluticasone furoate (FF), umeclidinium (UMEC) and vilanterol (VI) reduced all-cause mortality by 42 percent.

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What are the PEG Linkers?

This article is from ADCreview.

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The Things You Need To Know About Boronic Acids

Do you want to know something about Boronic Acids, maybe below article can help you know more.

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Elagolix can reduce menstrual bleeding caused by most common uterine tumors

Huateng Pharma is committed to providing cost-effective pharmaceutical products and services to customers worldwide with the belief of “Strive for the Human Health“. We can provide anti-cancer intermediate products, such as Elagolix which can reduce menstrual bleeding from most common uterine tumors .

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Two new diabetes drugs are good for the heart and kidneys

Diabetes mellitus (DM), commonly known as diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. Symptoms often include frequent urination, increased thirst, and increased appetite. If left untreated, diabetes can cause many complications. Acute complications can include diabetic ketoacidosis, hyperosmolar hyperglycemic state, or death. Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, damage to the nerves, damage to the eyes and cognitive impairment.

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Characterization of Antibody-drug Conjugates

Characterization of Antibody-drug Conjugates from ADC Review J.Antibody-drug

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Remdesivir and favipiravir could be useful in treating COVID-19

A new study published in the Journal of Biological Chemistry has revealed that drug Remdesivir could be useful in treating the deadly COVID-19 or the novel coronavirus that is infecting tens of thousands of people across the world.

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What are the latest technologies being used to develop ADCs?

Non-cleavable stable linkers are designed to degrade ADCs naturally similar to all naked antibodies by the proteolytic degradation. The non-cleavable linkers require intracellular uptake and are not degraded by blood enzymes allowing very high degree of extracellular stability.

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FDA OKs Baloxavir Marboxil for Patients at High Risk of Flu Complications

The US Food and Drug Administration (FDA) has approved a supplemental New Drug Application for baloxavir marboxil (Xofluza) for the treatment of influenza in individuals who are at increased risk of developing flu-related complications.

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cRGDfK-Grafted Small-Size Quercetin Micelles For Enhancing Therapy Efficacy Of Active Ingredient

Quercetin (QU) can significantly induce apoptosis of tumor cells and give play to other effect. However, the antitumor efficacy of quercetin was mostly evaluated at cellular level and rarely developed in vivo by intravenous injection. To solve this problem, researchers try to use DSPE-PEG to construct quercetin-loaded micelles, and the integrin ligand cRGDfK was grafted to modify the nanocarrier for enhancing its cancer-specific homing. And this cRGDfK-modified DSPE-PEG micelles significantly optimized quercetin therapeutic efficacy and pulmonary toxicity as well as lowered systemic toxicity.

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