Taxane anticancer drug docetaxel have entered into market of the United States and other 32 countries since 1995. It is used for the treatment of breast cancer and non-small cell lung cancer.
Clinical displays that it is useful for a variety of cancers and was involved in clinical trials in 1996.
32 patients with untreated advanced breast cancer in France are picked out. After an average of five courses of treatment, 5 patients with complete remission, 18 cases of partial remission, with a total effective rate 72%. Liver metastasis was unusually high efficiency, up to 82%, while the primary tumor and lymph nodes, and less efficient at 50% and 44%, respectively. The clinical observation of Canada and the United States also obtain similar results, to race on breast and ovarian cancer is at least quite paclitaxel.
For soft tissue sarcoma is used alone only three kinds of effective drug treatment of soft tissue sarcoma, which means they doxorubicin, ifosfamide, and dacarbazine. The researchers from the European cancer research and treatment of soft tissue and osteosarcoma group, docetaxel as first-line treatment of metastatic soft tissue sarcoma of the drug. The researchers noted that the effect of such patients with doxorubicin or ifosfamide.
For ovarian cancer, docetaxel treatment of ovarian cancer may play an important role. Previously were treated with cisplatin or carboplatin, ovarian cancer patients receiving 100 mg • m-2 West to race every three weeks, iv, 1h. The total efficiency of 30%. Late 81 patients, the effective rate of 20% in the European trial. For prostate cancer, hormone refractory prostate cancer on every 21d 75mg • m-2 docetaxel treatment efficiency of 20%.
24 Phase II clinical trials involve the use of docetaxel, 7 breast cancer trials, six NSCLC trial, 11 (for other types of cancer trials, each patient received an average of four courses, a total of 12 cases of breast cancer and 9 patients with lung cancer deaths, the death rate of other types of cancer patients in between 1% to 3%.
Adverse reactions that lead to chia seed treatment to stop fluid retention, skin toxicity, such as flushing, itching and rash, severe weakness and paralysis. Hematologic toxicity, including leukopenia, neutral neutropenia and febrile neutropenia incidence of the disease. 15.4% of patients require hospitalization, 1.7% of those who died due to sepsis. Non-hematologic toxicity, hair loss, sensory and motor nerve toxicity, nausea, vomiting, diarrhea, stomatitis, weakness. Toxicity occurred, the average cumulative dose of 400 mg • m-2, the average time to stop treatment for six weeks, the adverse effects disappeared after stopping time is about 18 to 25 weeks. 5 days before treatment were pretreated with the steroid hormones can significantly reduce fluid retention, severe skin reactions also decreased, the withdrawal rate reduced from 21.2% to 1.6%.
The docetaxel has encouraging performance in the clinical of variety cancer treatments. Multi-data show that the efficacy of paclitaxel is like the docetaxel’s. It is very likely to be widely used as first-line treatment for many types of cancers with paclitaxel.Source:http://www.cospcn.com
The application of tungsten in various industries
Steel Industry Most of tungsten applied in the production of special steels. The widely used high-speed steel was containing 9-24% of tungsten, 3.8-4.6% of chromium, 1-5% of vanadium, 4-7% of cobalt, 0.7-1.5% of carbon.
Magic effects of coconut oil
According to records, coconut oil can be regarded as the nobility of skin care plant extracts. It was rich in exotic tension of tropical plants, which can enhance the contractile force of the pores, perfectly beautify and nourish the skin.
The Evolution and Impact of Abamectin and Emamectin Benzoate in Pest Control
Abamectin and its derivative, emamectin benzoate, have emerged as pivotal substances in the realm of pest control, offering a broad-spectrum efficacy against various pests while maintaining a favorable environmental profile. As the agricultural industry continues to evolve, these compounds have adapted to meet the growing challenges of pest resistance, expanding their market applications and maintaining cost-effectiveness despite rising production costs.
