Biotin was originally called vitamin H, belonging to the family of water-soluble B vitamins. Biotin is composed by the imidazole ring and a tetrahydrocannabinol with valerate. It is the thiophene sulfur monocarboxylate. Nutritionists have extensive and in-depth study in functions of biotin.
Glucokinase is a key enzyme regulating liver glucose intake. The lack of biotin in mice glucose tolerance test curve, hepatic glucose phosphorylation and glycogen storage was significantly higher than non-deficient mice, which is caused by liver glucokinase activity. Sufficient quantities and pharmacological doses of biotin in the diet of liver glucokinase activity and is not limited to biotin-deficient mice, diabetic mice and in vitro cultured mouse liver cells are equally effective. Using molecular biology techniques can prove that the stimulus effect of biotin occurs at the transcriptional level.
Biotin as a coenzyme of the carboxylase, can also regulate gene expression, such as development and immune system processes in the body plays a broader role. The biotin regulates the expression of key genes of intermediary metabolism that role and biological factors involved in the maintenance of body glucose and lipid homeostasis role of. Biotin deficiency and to reduce glucose tolerance and glucose utilization. Excess of biotin can improve diabetes status. Supplementary biotin reduced the postprandial glucose concentration in patients with hereditary diabetic mice and induced non-insulin-dependent diabetic mice improved their glucose tolerance.
Pharmacological doses of biotin can reduce blood lipid levels. The cosmetic raw material suppliers’experiments show that healthy volunteers’ lipid concentration decreased after oral administration of biotin. Atherosclerosis and hyperlipidemia patients daily doses of 5 mg of biotin, the lower of hypercholesterolemia after 4 weeks. Biotin in the role of the carbohydrate metabolism and its pharmacological doses of non-toxic, showing biotin for the treatment of hyperglycemia and hyperlipidemia, obesity prevention and other aspects will have great application prospects.
Animal physiology, animal biochemistry, immunology and other disciplines, people continue to discover the biological function of the nutrients. In recent decades the study of biotin, biotin plays an important role in immune function, and promote the growth of immune organs. Early tests showed that biotin deficiency, combined with 32P into RNA and DNA was inhibited, resulting in the DNA content of the spleen cell division capacity and organ decline in cell proliferation was inhibited.
Biotin can improve animal performance in production. It is also used in the treatment of human diabetes. To date, research on action mechanism of biotin is already underway. As people gradually have deep understanding of the biotin, biotin as an indispensable additive in animal nutrition, the increasing roles will gradually be revealed. It can be predicted that biotin has a broader application in the production of animal, human health care and skin care.Source:http://www.cosprm.com
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