Astaxanthin is a kind of red pigment, can give salmon, shrimp and flamingos the pink color. Its chemical structure similar to the beta carotene (exist in carrots) and vitamin A. Astaxanthin is part of carrot group, astaxanthin can use chemical method getting from carotene system. At present, astaxanthin production has artificial synthesis and biological. Synthetic astaxanthin not only the price is expensive, also in structure, function, application and safety have significant difference with natural astaxanthin.
In physiological function, the stability and oxidative activity of synthetic astaxanthin is lower than the natural astaxanthin. In the biological security, use chemical means to produce astaxanthin will inevitably introduce impurity compounds, such as synthetic process of the natural outgrowth, etc., it will reduce the safety of its biological use.
Carotenes material can prevent the skin from uv damage. A recent research report show that in such materials, the effect of astaxanthin (super vitamin E) resist to damage is the best. A recent edition of the experiment of skin medical magazine published an article compared the effect of astaxanthin, Angle flavin and beta carotene resist the ultraviolet radiation damage. Dermatology institute of experts through the photos observation concluded that to resist human skin fibroblasts by ultraviolet radiation damage the astaxanthin’s effect is the best.
UVA will not only help generating the reactive oxygen species in the human body, but also restrain the hydrogen peroxide enzyme, super oxide dismutase catalytic effect, reduce skin fibroblasts of antioxidant ability. Therefore cosmetic raw material suppliers and dermatology experts say, it is necessary to use appropriate antioxidants to reduce uv damage.
In this study,astaxanthin manufacturer added astaxanthin, Angle flavin and beta carotene to the human body skin fibroblast cells. Thought the UVA irradiation 24 hours testing found that only astaxanthin can effectively prevent UVA to hydrogen peroxide enzyme induction inhibition, and beta carotene role is very little, Angle flavin role not almost observation. Similarly, to prevent UVA on super oxide dismutase induction inhibition, only astaxanthin and beta carotene have an effect on, Angle flavin do not have apparent effect.
At the same time, this report also studies the carotenes material slow down the ability of cell apoptosis. Cell apoptosis is often think as relevant to caspase 3 protease. The study found that UVA irradiation can lead to the levels of caspase 3 protease growing. But to skin fibroblasts add astaxanthin, caspase 3 protease secretion got obvious inhibition. Phase comparison, Angle flavin no inhibition, beta carotene but promote the secretion of caspase 3 protease, aggravate cell apoptosis. Researchers think that UVA will induce beta carotene to promote oxidation.
In order to get more specific understanding of astaxanthin defense mechanism, the researchers observed the HO - 1 gene in the composite effect of expression. HO - 1 is oxidative stress reaction of conventional index, the oxidation damage mechanism of stress reaction plays an important role. Interestingly, astaxanthin can inhibit caused by UVA irradiation HO - 1 forward adjust, while Angle flavin and beta carotene but have the opposite effect.
The researchers think this new discovery is show that astaxanthin can resist oxidation very clearly, the reason is that it can inhibit the generation of reactive oxygen species from the root, rather than simply remove has formed the reactive oxygen species. Therefore, astaxanthin can be used in preventing the injury of skin which caused by UVA induced safe and effectively.
With the rise of natural astaxanthin, astaxanthin production tend to develop natural astaxanthin biological sources, and start to mass production. At present, the rain raw red common in nature is recognized as the best biological which can produce natural astaxanthin. Therefore, the use of this kind of micro algae extracting astaxanthin undoubtedly have broad prospects for development, in recent years, has become the hot spot of international natural astaxanthin production.
Source:http://www.cosprm.com
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