Canada Pharmacy Reveals the Secrets of a Healthier Old Age
A new study has uncovered cells that cause aging. With this, it is now easier to develop Canadian drugs that will eradicate these cells from the human skin. "This research has identi...
A new study has uncovered cells that cause aging. With this, it is now easier to develop Canadian drugs that will eradicate these cells from the human skin.
"This research has identified a cell class that makes you old and makes you have age-related declines. We can now start to think about how you can get rid of them," he said.
Per van Deursen, "how organisms and people age is not really well understood, particularly not at a cell and molecular level. There are many theories about how we age and one of the theories that we investigated was that as we age, senescent cells start to accumulate and produce and secrete proteins and other factors that basically make the healthy neighboring cells that surround them less functional."
"In healthy young cells the p16 gene is not expressed," van Deursen added. "Later on, as we age, it becomes higher in our tissues."
"It's a proof of principle study. Now we know we can safely remove these cells in an animal model without causing any detectable harm," said van Deursen. Further, depression on unhealthy old age can now be eliminated – to buy Lexapro is not as necessary as it used to be.
"When they blocked the senescent cell process in mice prone to premature aging, they blocked the development of spinal arthritis, the loss of muscle, thinning of skin -- they were all reversed. Mice that should have looked prematurely aged were essentially normal," noted Dr. Gary Kennedy, director of the Division of Geriatric Psychiatry at Montefiore Medical Center in the Bronx.
"I thought it was a very interesting paper. I was actually surprised by the data -- no one else has been able to do this," added Dr. Julian Sage, an associate professor of pediatrics and genetics at Stanford University. He said "the genetic trick they used to eliminate the cell was intriguing, and he was equally interested in the finding that when you clear senescent cells that damage is curtailed."
"The tricky part in people will be how many senescent cells you can eliminate without killing the person, but to have an effect," Sage believes.
"It's an elegant study and a most important discovery," said Dr. Nir Barzilai, professor of medicine and genetics and director of the Institute for Aging Research at Albert Einstein College of Medicine, in New York City. He said "it's been suggested that senescence is a protective mechanism, against cancer, for example. However, this paper really suggests that senescence is not good or neutral, but in fact, if cleared, can be associated with less aging."
"If you attack the fundamental aging process, can you attack age-related illnesses as a whole?" Kirkland wondered. "Can you delay cancer, dementias, atherosclerosis, diabetes, obesity and its complications as a group?"
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