Cancer-free Bones with Canadian Drugs

CanadaDrugsOnline.com highlights the importance of sturdy bones. The skeletal structure supports and enables the entire body to stand.  Without it everything will become clumsy and lifeless. In connection, Zometa is important in treating worse bone conditions like cancer. 

Generic Zometa is in a group of medicines called bisphosphonates. Zoledronic acid inhibits the release of calcium from bones. Zometa is used to treat high blood levels of calcium caused by cancer. Zometa also treats multiple myeloma or bone cancer that has spread from elsewhere in the body. 

Zometa can harm your kidneys. This effect is increased when you also use other medicines harmful to the kidneys, such as: chemotherapy, antiviral medication, pain or arthritis medicine, injected antibiotics, or medicines to treat a bowel disorder or prevent organ transplant rejection. You may need dose adjustments or special tests if you use any of these medications. 

You should not buy Zometa and take it if you are allergic to zoledronic acid or similar medicine such as alendronate (Fosamax), etidronate (Didronel), ibandronate (Boniva), pamidronate (Aredia), risedronate (Actonel), or tiludronate (Skelid). You should also not receive Zometa if you have: low levels of calcium in your blood; or if you are pregnant or breast-feeding. 

Some people using medicines similar to Zometa have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. 

You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia, and dental surgery or pre-existing dental problems. 

Bone is one of the most common locations for metastasis. While any type of cancer is capable of forming metastatic tumors within bone, the microenvironment of the marrow tends to favor particular types of cancer, including prostate, breast, and lung cancers. Particularly in prostate cancer, bone metastases tend to be the only site of metastasis. 

Under normal conditions, bone undergoes a continuous remodeling through osteoclast-mediated bone resorption and osteoblast-mediated bone deposition. These processes are normally tightly regulated within bone to maintain bone structure and calcium homeostasis in the body. Disregulation of these processes by tumor cells leads to either osteoblastic or osteolytic phenotypes. Regardless of the phenotype, though, bone metastases show osteoclast proliferation and hypertrophy. 

Bone metastases are a major clinical concern that can cause severe pain, bone fractures, spinal cord compression, hypercalcemia, anemia, spinal instability, decreased mobility, and rapid degradation in the quality of life for patients. Patients have described the pain as a dull ache that grows worse over time, with intermittent periods of sharp, jagged pain. Even under controlled pain management, these periods of breakthrough pain can occur rapidly, without warning, several times a day. 

·         Effects of bone metastasis

·         severe pain

·         bone fractures

·         spinal cord compression

·         hypercalcemia

·         anemia

·         spinal instability

·         decreased mobility