Chronic granulomatous disease is transmitted in 50% of the cases as a recessive sex-linked trait. Most cases of chronic granulomatous disease are transmitted as a variation on the X chromosome. It are therefore called a "X-linked trait.
Chronic granulomatous disease is inherited disorder of phagocytic cells. These cells usually destroy bacterium. Chronic granulomatous disease causes repeated bacterial. Some of the light-colored blood cells do not make as easily as they should, then children with CGD are inclined to developing infections. CGD affects persons of all races. CGD affects about 1 in 200,000 folk in the United States, with at least 20 original cases diagnosed each year.
The stricken gene on the X chromosome codes for the gp91 protein p91-PHOX (p is the weight of the protein in kDa; the g means glycoprotein. CGD can too be transmitted in an autosomal recessive style and affects new PHOX proteins. Fungal infections in CGD patients have been reported to account for roughly 20% of infections. The almost popular fungal infections in these patients are caused by Aspergillus species Infections are too caused by unique opportunistic organisms such as Chromobacterium violaceum; Serratia marcescens; and Nocardia, Legionella, and uncharacteristic Mycobacteria species.
Acute infections should be treated sharply with accurate antibiotics. The antibiotic cotrimoxazole (Bactrim, Septrin) has improved things tremendously for children with CGD. Interferon-gamma may too be useful in reducing the amount of serious infections. Antibiotic trimethoprim-sulfamethoxazole to forbid bacterial infections. This drug too has the welfare of sparing the natural bacterium of the digestive parcel. Long-term antibiotic treatments may assist to cut infections. But earlier death is typically an outcome of repeated lung infections. Fungal transmission is usually prevented with itraconazol.
Gene therapy is currently possible treatment for chronic granulomatous disease. Genetic counseling is recommended for prospective parents with a family history of chronic granulomatous disease. Advances in genetic screening, and increasing use of chorionic villus sampling, have made early recognition of chronic granulomatous disease possible. However, the practice is not yet widespread or fully accepted. Carrier status in the female can be identified by testing.
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