Detailed introduction about biotin

Easy to combine with a protein in egg white, eat lots of raw protein will hinder the absorption of biotin, lead to biotin deficiency, such as hair loss, weight loss, dermatitis. Biotin plays an important role in the biochemical reaction pathways of fat synthesis, gluconeogenesis.

Biotin is the savior of the bald family, not only in preventing hair loss and baldness are very effective, but also can prevent the modern common juvenile white hair. It also plays an important role on skin health, is a common cosmetic raw material. As for the efficacy of steadying the nervous system has not yet been confirmed, but for the depression, insomnia, it certainly has some helpful.

In 1936, two German scientists were extracted a crystalline substance from duck yolk cooked, it is necessary for the growth of yeast, known as biotin. Biotin widely found in various organisms in nature, an indispensable element to maintain humans and animals’ healthy, and therefore become famous. Because of it was widely distributed in the food, almost every food contains a small amount of biotin, combined with people’s daily required amount is small, so people are generally not lack of this vitamin.

Biotin is a colorless, needle-like crystals, with a combination fused ring of urea and thiophene, also with valeric acid side chain; very slightly soluble in water and ethanol, insoluble in common organic solvents. Stable for several days in moderate intensity acid and neutral solutions, in alkaline solution has poor stability. Fairly stable at ordinary temperatures, but the high temperature and oxidant can make it loss activity.

Oral biotin is rapidly absorbed from the stomach and intestines, 80% biotin in free form exist in blood, distributed in body tissues, and more content in the liver, kidney, after medicated, most of the biotin discharge by the urine in the original shape, only a small part turn into the biotin sulfur oxides and double down biotin.

Biotin combined with the enzyme participated in the carbon dioxide fixation and carboxylation process in vivo, related with important metabolic processes of the body, such as the main biochemical reactions of pyruvate carboxylase and transformed into oxaloacetate and acetyl coenzyme A carbonylation into malonyl coenzyme A, sugar and fat metabolism. It is also the growth factor of certain microorganism, a very small amount (0.005mg) can make the test bacterial growth. E.g. neurospora crassa growth requires a very small amount of biotin. People’s daily need is about 100 to 300 micrograms.

To gluconeogenesis, the combined effects of fatty acids and the metabolism of certain amino acids, biotin is also a key regulatory element, and can play a role in promoting the synthesis of certain proteins by helping produce energy; can also help the cells growth at the same time, manufacturing fatty acids, metabolism of carbohydrates, fats and proteins, and contribute to the utilization of B vitamins; promote sweat glands, nerve tissue, bone marrow, male gonads health; maintain normal operation and growth of skin and hair, reduce the symptoms of eczema, dermatitis; prevent white hair and hair loss, helps the treatment of baldness; also involved in the metabolism of vitamin B12, folic acid, pantothenic acid; promote urea synthesis and excreting; improve the body's immune function. Biotin is a coenzyme of a variety of enzymes in the human body, involved in fatty acid and carbohydrate metabolism in the body; promote protein synthesis.

Source:http://www.cosprm.com