Due to the living environment and lifestyle changes, as well as population aging, survival pressure increases, and other objective factors, resulting in cancer incidence in China is rising, become the first lethal disease.
Cancer drug sales also go up, and maintain a stable high-speed growing. The antineoplastic market growth rate is 33.22% in 2006, and compared the first half of 2007 with the same period in 2006, the growth rate is 33.86%.
According to pharmaceutical raw materials suppliers, the mechanism of action is to strengthen the tubulin polymerization and inhibition of microtubule depolymerization, leading to the formation of stable, non-functional microtubule bundle, thus destroying the tumor cell mitosis. Docetaxel in the intracellular concentration is 3 times higher than paclitaxel, and retention for a long time in intracellular, this is the reason why docetaxel antitumor is more activity than paclitaxel in vitro tests. In vivo test, it has effects on mice with colon cancer, breast cancer, lung cancer, ovarian tumors, graft and others. To cisplatin, etoposide, 5Fu or paclitaxel-resistant cell lines, docetaxel does not produce cross-resistance.
In many anticancer drugs, natural plant anticancer drugs had the largest share, accounted for 27.0% share, followed by anti-metabolic tumor drug, accounting for 26.1%. in the top of 10 antineoplastic of a single product, the plant-based anticancer occupy two seats, paclitaxel and docetaxel, respectively, occupy the first two seats. Since 2002, the plant-based anticancer compound annual growth rate is 25.5%, below the average of the cancer drug, related to anticancer drugs in recent years innovation less, most of the products have been sold to the platform, and the growth rate of the main products paclitaxel slowing down. In contrast, docetaxel is the fastest growing product in such products.
Plant class of anticancer drugs in the first half of 2007, paclitaxel accounted for 44.1% share of the market, become the first and docetaxel followed, accounted for 39.7% share. These two species occupy the plant anticancer 83.8% share, in other varieties, vinorelbine accounted for 6.7%, elemene accounted for 3.3%, HCPT accounted for 3.2%, and other species occupy only 3% of the market share.
Taxol has maintained a stable growth trend, the annual compound growth rate is 23.9% since 2002. However, due to its large number of manufacturers, competition is fierce, the seven top-ranking manufacturers, no significant growth, or even decline, while the sales of docetaxel manufacturer has grown rapidly since 2004, the competition has become more and more fierce.
Docetaxel belongs to microtubule depolymerization inhibitor, belonging taxanes, international approval for treating advanced breast cancer and non-small cell lung cancer. Docetaxel injection indications for advanced ovarian cancer, non-small cell lung cancer, breast cancer. Since 2002, docetaxel has maintained a high growth trend, since 2002, the annual compound growth rate is 88.5%, much higher than similar species, although total sales lagged behind paclitaxel, but the rapid growth catch up with paclitaxel, become the boss of similar drugs is around the corner.
Source:http://www.cospcn.com
The application of tungsten in various industries
Steel Industry Most of tungsten applied in the production of special steels. The widely used high-speed steel was containing 9-24% of tungsten, 3.8-4.6% of chromium, 1-5% of vanadium, 4-7% of cobalt, 0.7-1.5% of carbon.
Magic effects of coconut oil
According to records, coconut oil can be regarded as the nobility of skin care plant extracts. It was rich in exotic tension of tropical plants, which can enhance the contractile force of the pores, perfectly beautify and nourish the skin.
The Evolution and Impact of Abamectin and Emamectin Benzoate in Pest Control
Abamectin and its derivative, emamectin benzoate, have emerged as pivotal substances in the realm of pest control, offering a broad-spectrum efficacy against various pests while maintaining a favorable environmental profile. As the agricultural industry continues to evolve, these compounds have adapted to meet the growing challenges of pest resistance, expanding their market applications and maintaining cost-effectiveness despite rising production costs.
