How about characteristics of clinical application of docetaxel injection? Docetaxel’s clinical applications are characterized by its pharmacological effects. Docetaxel is a paclitaxel antitumor drug.
It plays anti-tumor role by interfering with cell microtubule network which is necessary for mitosis and interphase cell function. Docetaxel can combine with the free tubulin to promote tubulin assembly into stable microtubules. Meanwhile, it inhibits the depolymerization, resulting in production and fixation of microtubules which is in loss of normal function. Thus it inhibits cell mitosis. Combination of docetaxel with microtubule does not change the number of the original wire. The point is different with the most of spindle toxicity drugs which are applied in clinical trials. In hospitals or pharmacies, docetaxel price is acceptable.
Which kind of disease is docetaxel injection suitable for? Docetaxel is suitable for the treatment of the selection of failure of chemotherapy in advanced or metastatic non-small cell lung cancer. Unless a clinical contraindication, the initial treatment should including the anti-cancer drugs. Docetaxel is also used in the treatment of advanced or metastatic non-small cell lung cancer when there is a failure in cisplatin-based chemotherapy.
Why erythemas occur on hands and feet after people use docetaxel? Docetaxel has adverse reactions on skin. It often shows the formation of erythema and it is mainly seen in the hands, feet. It may also occur in the local arm, face and chest rash, sometimes accompanied by itching. The rash may often be in the infusion Dorsey him after the game within a week, but may recover before the next infusion.
What issues need people’s attention in use of docetaxel? Docetaxel must be used in cancer chemotherapy drug application experience under the guidance of a doctor. Leukocyte count of patients less than 1500/m3 disabled. Pregnancy, lactating women and children disabled. Before the treatment, patients should take glucocorticoids such as dexamethasone, in order to reduce the incidence of fluid retention. In opinions of pharmaceutical raw materials suppliers and researchers, during the treatment period, patients should regularly monitor the number of blood cells.
How about docetaxel’s metabolism process and absorption situation in the body? Docetaxel has its metabolism in hepatic. It is mainly duct from feces through the bile. While urinary excretion only accounts for 5% to 7%. For patients with abnormal liver function, the clearance rate of docetaxel reduces in vivo. But the age difference will not make significant change for docetaxel’s drug activity in human body.
Source:http://www.cospcn.com
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