Biotin involves in the metabolism of body's three major nutrients as a cofactor for carboxylation, decarboxylation and dehydrogenation enzymes. It is a necessary and important nutrient foe human and animal body.
Only Ã-biotin in a variety of isomers has biological activity. Under normal circumstances, the biotin is quite stable. It will be damaged only in acids, alkalis, formaldehyde, and UV. Avidin is a glycoprotein in egg white. It can combine with biotin so that it can not be absorbed in the intestine. After the heat treatment, biotin is able to be reused.
Biotin as a cofactor of many enzymes of the body, play an important role in the metabolic process of carbohydrates, lipids, proteins and nucleic acids. The biotin enzymes in mammals are: pyruvate carboxylase, acetyl coenzyme A carboxylase, propionyl coenzyme A carboxylase and ² methyl butene coenzyme A carboxylase are dependent on the activation of ATP and Mg2.
In carbohydrate metabolism, biotin enzyme catalyzed carboxylation and decarboxylation, is an essential component of the citric acid cycle, to participate in food metabolism and gluconeogenesis to maintain stable blood sugar. Biotin as a coenzyme of pyruvate carboxylase, pyruvate carboxylation to oxaloacetate, and impact of oxalyl succinic acid is converted to ±-ketoglutaric acid, Ping check the acid converted to pyruvic acid, succinic acid, and pyruvate mutual changed.
Biotin as a coenzyme of acetyl coenzyme carboxylase involved in fatty acid synthesis. As propionyl carboxylase, coenzyme, and odd carbon fatty acid ²-oxidation of essential substances. In addition, biotin and acetylcholine synthesis and cholesterol metabolism. Biotin in protein synthesis, amino acid deamination, drift methotrexate synthesis and leucine, tryptophan metabolism plays an important role for a variety of amino acids necessary for the transfer of decarboxylation.
Higher biotin utilization in yeast, bread, meal, corn and other feed, fish meal, meat and bone meal and wheat, barley, sorghum, bran and other cereal feed biotin was combined with the state, the utilization is very low. Diet containing more carbohydrates, especially glucose ingredient, can promote the growth hormone absorption. When the feed contains raw egg, which avidin binding, thus affecting its use. Antibiotics (such as sulfa, etc.) will affect the intestinal bacterial synthesis of biotin.
Biotin is an important cosmetic raw material. It can not only be used in human cosmetics, but also improve the reproductive performance of sows. Diets supplemented with biotin may improve the reproductive performance of sows. Addition of biotin can increase the number of sows. Biotin can shorten the time of weaning and interval. In different types of diet, the supplement of biotin will improve daily gains of growing pigs and feed’s efficiency.Source:http://www.cosprm.com
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