In recent years, due to the wide range applications of ionizing radiation in human life, especially for its effects in cancer treatment, food preservation, agriculture, industrial and energy production, there is an urgent need to develop efficient non-toxic radiation protectants.
Currently, the available radiation protectants are expensive and have adverse reactions. Pharmaceutical raw materials suppliers are actively looking for new radiation protective agents. These include the antioxidant enzymes, nitric oxide, melatonin, growth factors, gene therapy and heat therapy. In addition, the plant extract as a new type of radiation protectants, it has clear efficacy and low adverse reactions. It arouses extensive attention for radiation protection community.
Citrus fruit and leaves are rich in radiation protection substances. Its main active ingredient glycoside class, such as lemon factors, naringenin. Such compounds of its fruit and leaf dry weight of 5%. Citrus flavonoid glycoside class can reduce capillary fragility and improve blood flow, such substances are known as vitamin P. People are also such substances used in anti-cancer and anti-ulcer. Naringenin, lemon factors showed strong antioxidant activity, reducing erythrocytes and micro nuclear incidence. It protects the mouse bone marrow.
Peppermint is an aromatic plant, with the role of the treatment of nausea, vomiting. Studies have shown that in front of the ³-ray irradiation, oral peppermint extract can effectively increase the radiation-induced endogenous spleen colony formation rate, peppermint mice treated with spleen weight significantly increased bone marrow chromosome damage reduced survival rate, blood parameters improved.
Orchid is a widely used herbal medicine in the Indian medical system. For the treatment of infections, skin diseases, colds and coughs, etc., in addition to the treatment of liver diseases and malaria, and also has antibacterial, antiviral, anticancer, antioxidant and immune role. Water and alcohol extracts of the leaves has the characteristics of radiation protection, the aqueous extract can more effectively improve the survival rate. Compared with traditional radioprotector WR-2721, its extract is standard radiation protectants. The main active ingredient of orchid perfume extracts are oriental polygonum flavin and Wengsaining. The experiments confirmed that these two active ingredients are low or non-toxic substances.
Podophyllum can reduce the radiation damage, especially to alleviate the role of the adult mouse radiation-induced hematopoietic syndrome. Increased superoxide dismutase activity in the intestines, liver GST and SOD levels. Prevention of neonatal rats in utero radiation-induced neuronal damage. Podophyllotoxin is the main ingredient of podophyllum plant extracts.
In the study of radiation injury protection drugs, natural plant extracts have low toxicity, fewer side effects and other advantages. It has broad prospects. Strengthening the study of anti-radiation effect of natural plant extracts has great significance to the development of new anti-radiation drugs.
Source:http://www.cospcn.com
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