Research the role of glutathione

Glutathione is by the glutamic acid, cysteine and glycine combined with a three peptide, cysteine of thiol as its active group (the glutathione often known as G - SH), different from iodine acetic acid, heavy metal salt complex of mustard gas (a gas), lead, mercury, arsenic, etc, the integration of detoxification. Glutathione (especially liver cell glutathione) has very important physiological role is the integration detoxification, can with some drugs (such as paracetamol), toxin (e.g., free radicals, heavy metal), such as the combination, participate in biological transformation effect and put in the harmful poison into harmless substance, expels from the body.

Glutathione have reduced (G - SH) and oxidation type (G - S - S - G)two forms, in the physiological conditions with reduced glutathione to account for the vast majority. Glutathione reductase catalytic two type the each other between variable. The enzyme coenzyme for phosphate sugar bypass metabolic provides the NADPH.

Another major physiological function of glutathione as the body is a kind of important antioxidant, it can remove the body of free radicals, clean and purify the body environmental pollution, so as to enhance the people's physical and mental health. Because of reduced glutathione itself is susceptible to certain material oxidation, so in the body it can protect many protein and enzyme on molecules of sulfhydryl will not be oxy-genated by harmful material such as free radical oxidation, so that the protein and enzyme on molecular play its physiological function. Human red blood cells of GSH content many, the protection on the red cell membrane protein sulfhydryl in reducing state, prevent hemolysis has an important meaning, but also can protect the hemoglobin from hydrogen peroxide oxidation and free radical oxidation etc so as to make it regular in play to transport oxygen ability. Red blood cells of hemoglobin in the hydrogen peroxide oxidant, such as, under the action of the ferrous iron oxidation for ferric iron, make the hemoglobin into methemoglobin, thus losing the ability with oxygen. Reduced glutathione can directly combined with some oxidant like hydrogen peroxide, such as combination of formation water and oxidation type glutathione, can also will methemoglobin revert to hemoglobin.

In addition, vitamin C is a kind of important antioxidants in the body. Because of vitamin C can reversibly hydrogenation or dehydrogenation, so the vitamin C plays an important role in many redox reaction in the body.

For example, many enzyme active group is the sulfhydryl (- SH), vitamin C can maintain - SH in reducing state and keep the activity of enzymes, Vitamin C can oxidize type glutathione into reduced glutathione (GSH), make the body metabolism produce hydrogen peroxide (H2O2) reduction; Vitamin C can also protect vitamins A, E and some B vitamins from oxidation. Therefore, compared with vitamin C while using glutathione can improve the efficacy.

At present, glutathione manufacturer have created glutathione drugs, widely used in clinical, and hepatitis, hemolytic disease and keratitis, cataract and retinal disease, etc. In addition to use its sulfhydryl with chelating heavy metal, fluoride, mustard gas toxins such as poisoning outside, , as the auxiliary treatment drugs.

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