The main application of glutathione in medically
From glutathione supplier, we know that glutathione exists in all living cells, with higher levels in yeast, cereal seed germ, human and animal heart, liver, kidney, red blood cells and the lens of the eye.
The ratio of reduced glutathione and oxidized glutathione in normal human body is 100:1, the normal concentration of glutathione in whole blood is about 37.1mg/dl, and the body's liver and kidney is glutathione’s mainly synthesis, metabolism, and excretion organs. The main biological functions of glutathione protection in vivo protein sulfhydryl and thus maintain normal biological activity of the protein, but it also is a coenzyme and prosthetic group of many enzymes. Closely related to the molecular structure of important biological functions of glutathione, such as the glutathione molecule mercapto participation oxygen radicals, detoxification and other important functions; contained in the ³-glutamine key able to maintain the stability of the molecule and participation transporter amino; the glutathione glycine and cysteine residues involved in the metabolism of bile acids and so on.
Recent years, with the in-depth studies of physiological and biochemical aspects of glutathione in the medical, food, health care, cosmetics material is caused by the growing attention. Glutathione anti-free radicals are mainly used in the medical, protect cells, glutathione as a substrate for glutathione peroxidase inhibit lipid peroxidation, protecting the cell membrane to restore cell function. Glutathione can protect cells embedded the sulfhydryl enzyme activity (such as ATP enzyme), to prevent the result of protein denaturation due to the oxidation of the mercapto group (such as hemoglobin), to reduce the free radical attack on DNA thus reducing the DNA damage and mutation. Glutathione also by a radical of the mercapto group and in vivo binding acids converted easily metabolized, thus accelerating the excretion of free radicals.
Get rid of exogenous toxic substances (including drugs), glutathione can be directly combined with some of the poison and excreted; or through liver cytochrome P metabolising enzymes oxidation and hydroxylation, then under the role of glutathione S-transferase, glutathione-binding to molecules compounds, the material leaving poison inactivation and increase the water-soluble, finally, excreted in the bile and kidneys by the degradation way. Promote cell protein synthesis of glutathione by the ³ glutamyl transporter enzyme into the cells and involved in a number of amino acids, thus contributing to the intracellular translocation protein synthesis ³-glutamyl cycle.
Involved in methyl transfer, transfer propylamino reaction to maintain the normal function of the liver cells of glutathione can strengthen the methyl transfer and turn propylamino reaction, which can promote the synthesis of ATP and clotting factors, and can promote the metabolism of amino acids and fat, promote femalehormone inactivation and reduce hypoalbuminemia.
Involved in the metabolism of bilirubin, glutathione under the role of glutathione S-transferase, load the unconjugated bilirubin into microsomal, make it combined with glucuronide and excreted in conjugated bilirubin.
Promote bile acid metabolism, reduce bleeding tendency, glutathione can provide glycine and taurine to liver, promise glycine and taurine-type combination of bile acid synthesis, and promote the digestive tract intake the fat-soluble vitamins (A, D, E, K), glutathione can be provided to the liver in the glycine and taurine, promise glycine and taurine type binding bile acids synthesis, promote the gastrointestinal absorption of fat-soluble vitamins (A, D, E, K),thereby promoting the hepatic synthesis of vitamin K dependent coagulation factors (II, V, VII), to reduce bleeding tendencies.
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