The extensive application of glutathione

The pharmacological effects of glutathione: reduced glutathione is a tripeptide composed of glutamic acid, cystine and glycine, it is a cofactor of glyceraldehyde dehydrogenase, also the coenzyme of ethanediyl aldehyde enzymes and triosephosphate dehydrogenase which can involve in the in vivo TCA cycle and glucose metabolism, make the body get the high energy. Glutathione can activate a variety of enzymes, such as the body’s mercapto group (-SH) enzyme, coenzyme, etc. thereby contributing to the carbohydrate, fat and protein metabolism, and can also affect the metabolic processes of the cells, is an intracellular important regulator of metabolic substances.

In addition, glutathione in the body exist in two forms of reduced glutathione and oxidized glutathione, its active ingredient is glutathione, can participate in vivo redox processes. Under the action of glutathione transferase, glutathione can combine with the peroxides and free radicals to anti oxidants destruct mercapto, protection of cell membrane protein containing a mercapto group and a mercapto group-containing enzyme is not destruction against free radical damage to vital organs. Reduced glutathione is widespread in the animal and plant’s cells, and content in the liver and lens more. Now can be produced by chemical synthesis or fermentation.

Reduced glutathione is cofactor of glyceraldehyde phosphate dehydrogenase and the coenzyme of glyoxal enzymes triosephosphate dehydrogenase, involved in the body of the citric acid cycle and glucose metabolism, make the body get high energy. Can activate and protect a variety of enzymes, such as sulfhydryl (-SH), in vivo cholinesterase enzyme, so that the body against iodoacetic acid, mustard gas, free radicals (such as superoxide anion), heavy metals (such as mercury, lead), poisoned epoxide and other harmful substances, thereby contributing to the carbohydrate, fat and protein metabolism, can also affect the cell's metabolic processes. Promote eye tissue metabolism, inhibit crystal protein thiols instability, prevent the development of cataracts and retinal disease, which can be used to keratitis, corneal trauma. These diseases before reaching old age, began regular use of such antioxidants can play a preventive role. There are also good increasing role in vision.

Glutathione suitable for a variety of liver diseases, especially alcoholism, liver disease, drug-induced liver disease (including anti-cancer drugs, anti-tuberculosis drugs, neuropsychiatric drugs, antidepressants, acetaminophen and Chinese medicine) positive effect on the infectious liver disease - hepatitis B, chronic active hepatitis C also improved the symptoms, signs, and recovery of liver function. Used for poisoning rescue for heavy metals, organic solvents. Prevention and treatment of radiation injury, leukopenia disease and radiation-induced bone marrow tissue inflammation. It can also be used as cosmetic raw materials, used for facial pigmentation, sweat stain and a variety of causes pigmentation. For eye drops to treat early age-related cataracts, can also be used for corneal ulcers, corneal epithelial peeling, keratitis.

After the reduced glutathione treatment, it may cause rash, stomach pain, nausea, vomiting, injection of local mild pain. A small number of patients using the drug drops may occur itching, irritation, ocular hyperemia, blurred vision and other symptoms, after drug withdrawal it will disappear.

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