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BOTOX vs. ... SKIN CAREOn April 15, 2002, the FDA approved Botox® to treat frown lines. Botox® was first approved in December 1989to treat two specific eye muscle ... ... an


On April 15, 2002, the FDA approved Botox® to treat frown lines. Botox® was first approved in December 1989
to treat two specific eye muscle disorders, “Blepharospasm” and “Strabismus” and subsequently approved in
December 2000 to treat Cervical Dystonia, a neurological movement disorder that causes severe neck and
shoulder contractions.1

To gain the approval for use with frown lines, a clinical study involving 405 mostly women over 50 with moderate
to severe frown lines were injected with Botox® cosmetic and after 30 days frown lines were evaluated. The frown lines were eliminated for approximately 120 days at which time re-injection was required. The FDA guidelines were
injections to incur no more frequently than once every three months and the lowest effective dose should be used.

The study highlighted the following common adverse side effects:

Respiratory infection
Flu symptoms
Droopy eyelids
Less frequent but adverse reactions in approximately 3% of patients included pain in the face, redness
at the injection site, and muscle weakness. While the adverse reactions were termed temporary, they could last months.

The FDA approved Botox® as a prescription drug, thus, requiring medical supervision. The actual name
for Botox® cosmetic is Botulinum Toxin Type A; it’s actually produced from the bacterium Clostridium Botulinum.

What actually occurs is an injectible form of sterile purified toxin, in a very small dose, is injected into the
affected muscles to block and release the chemical acetylcholine that would otherwise cause contraction in
the muscle. The toxin actually paralyzes the injected muscle.

Interestingly, the Botulinum Toxin has been known for centuries. As early as 1895, a professor (Emile Pierre van Ermengem of Ellezelles, Belgium) identified the original toxin from Bacterium Bacilus Botulinus. It was later renamed in the 1920’s as Botulinum Toxin Type A, generic name Botox®, which is a registered trademark. Dr. Herman Sommer, at the University of California San Francisco subsequently provided the data sufficient for future medical studies.

In the 1950’s, Dr. Vernon Brooks2 discovered that the Botulinum Toxin, when injected directly into an active
or hyperactive muscle included the release of acetylcholine from motor nerve endings, thus, inducing a temporary
paralysis of a targeted muscle.

In the 1960’s and 1970’s, Dr. Alan Scott, M.D. of the Smith-Kettlewell Eye Research Foundation began effectiveness
testing with monkeys to determine if the drug might have effective therapeutic modalities.

For the next 20-30 years, Dr. Scott collaborated with Dr. Schantz of the University of Wisconsin to
further develop product samples.3

In the late 1970’s, Dr. Scott formed a company named Oculinum, where he continued to study the drug
with monkeys and in 1978 received permission from the Food & Drug Administration to test on human clinical studies.
In 1988, Allergan acquired the rights to distribute Dr. Scott’s Botox® Toxin Type A product. The current manufacturer, Allergan Inc., is located in Irvine, California.

Current side effects in actual applications are as follows (as a % of total side effects):

Upper Respiratory Infection – 11%
Neck Pain – 11%
Headache – 11%
Drooping Eyelids – 21%
Eye Dryness – 6%
All others – 40%
While Botox® is the rage today, alternatives for professional skin care, such as the all new NutriMinC RE9
anti-aging skin care system from IH Distribution LLC, is an excellent alternative. More information can be seen at IH Distribution’s products are all-natural, botanically-based, pH correct, hypoallergenic,
dermatologist tested, NEVER tested on animals, contain no animal products or by-products, made without
mineral oil and formulated without dyes or chemical fragrances.

The idea of injecting your face every three months, at a cost of up to $1,200 per injection, with toxins,
given known side effects and the significant discomfort of the injections, from a product continually tested on
monkeys should drive consumer’s research to other alternatives.

Webster’s dictionary confirms toxins are “any of various poisons produced by microorganisms and
causing certain diseases” or “any poisons secreted by plants or animals”.4

Copyright © IH Distribution LLC, 2004
No material may be use without the expressed permission of IH Distribution LLC

1. FDA T02-20 April 15, 2002
2. Schantz, EJ, Historical Perspective EDS. Therapy with Botulinum Toxin New York, New York, Marcelle Dekker Inc. 1994
3. Schantz EJ, Johnson EA, Botox® Toxin Persp Biomed 1997; 40 (4) 317327
4. Webster’s New World Dictionary and Thesaurus, Copyright © 1966 by Simon & SchusterBusiness Management Articles, Inc.


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