What are the Worst Side Effects of Meloxicam?

Jun 30


Jane Scaplen

Jane Scaplen

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Let’s explore the worst side effects of meloxicam tablets, providing detailed information on each and answering frequently asked questions.

What are the Worst Side Effects of Meloxicam Tablets?

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) commonly prescribed to alleviate pain and inflammation associated with conditions such as arthritis. While effective for many individuals,What are the Worst Side Effects of Meloxicam? Articles meloxicam can cause a range of side effects, some of which can be severe. This article explores the worst side effects of meloxicam, providing detailed information on each and answering frequently asked questions.

Serious Side Effects Meloxicam

Gastrointestinal Issues

  • Ulcers and Bleeding: Meloxicam can cause stomach and intestinal ulcers, which may lead to serious bleeding. Symptoms include severe stomach pain, black or bloody stools, and vomiting blood.
  • Perforation: In rare cases, meloxicam can cause a hole to form in the stomach or intestines, a condition known as perforation. This is a medical emergency.

Cardiovascular Problems

  • Heart Attack and Stroke: Meloxicam may increase the risk of heart attack and stroke, particularly when used long-term or at high doses. Symptoms include chest pain, shortness of breath, weakness on one side of the body, and slurred speech.
  • Hypertension: The medication can also lead to elevated blood pressure, which can exacerbate cardiovascular risks.

Kidney Damage

  • Acute Kidney Injury: Meloxicam can impair kidney function, leading to acute kidney injury. Symptoms include reduced urine output, swelling in the legs and ankles, and fatigue.
  • Chronic Kidney Disease: Prolonged use can contribute to the development or worsening of chronic kidney disease.

Liver Damage

  • Hepatotoxicity: Although rare, meloxicam can cause liver damage, which may manifest as jaundice (yellowing of the skin and eyes), dark urine, severe fatigue, and abdominal pain.

Allergic Reactions

  • Anaphylaxis: This is a severe, potentially life-threatening allergic reaction that can cause difficulty breathing, hives, swelling of the face and throat, and a rapid drop in blood pressure.

Skin Reactions

  • Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN): These rare but serious conditions cause severe blistering and peeling of the skin, and can be fatal.

Common Side Effects

While not as severe, the following common side effects can still impact the quality of life and may require medical attention:

  • Nausea and Vomiting
  • Diarrhea or Constipation
  • Headache
  • Dizziness or Lightheadedness
  • Edema (Swelling)
  • Rash or Itching


How can I reduce the risk of severe side effects while taking meloxicam?

To minimize the risk of severe side effects, follow these guidelines:

  • Take the Lowest Effective Dose: Use the smallest dose that relieves your symptoms.
  • Short-term Use: Limit the duration of use as much as possible.
  • Take with Food: Consuming meloxicam with food can reduce the risk of gastrointestinal issues.
  • Regular Monitoring: Have regular check-ups with your healthcare provider to monitor for potential side effects.

Who is at higher risk for severe side effects from meloxicam?

Individuals with the following conditions or risk factors are at higher risk:

  • History of Ulcers or Gastrointestinal Bleeding
  • Cardiovascular Disease
  • Kidney or Liver Disease
  • Allergies to NSAIDs
  • Older Adults: Age increases the risk of side effects.

Can I take meloxicam with other medications?

Meloxicam can interact with other medications, increasing the risk of side effects. Inform your healthcare provider about all medications you are taking, especially:

  • Other NSAIDs: Combining with other NSAIDs increases the risk of gastrointestinal and cardiovascular side effects.
  • Blood Thinners: Increased risk of bleeding.
  • Antihypertensives: NSAIDs can reduce the effectiveness of these medications.

What should I do if I experience severe side effects?

If you experience any severe side effects, seek medical attention immediately. For less severe but concerning symptoms, contact your healthcare provider for guidance.

Are there alternatives to meloxicam?

Yes, there are alternative medications and treatments for managing pain and inflammation:

  • Other NSAIDs: Such as ibuprofen or naproxen.
  • Acetaminophen: For pain relief without anti-inflammatory effects.
  • Corticosteroids: For severe inflammation.
  • Physical Therapy and Lifestyle Changes: Exercise, weight management, and physical therapy can also help manage symptoms.


While meloxicam is an effective medication for pain and inflammation, it is essential to be aware of its potential side effects, especially the severe ones. Always use meloxicam under the guidance of a healthcare provider and report any concerning symptoms promptly. By understanding the risks and taking appropriate precautions, you can manage your condition effectively while minimizing adverse effects.