Eosinophilic granuloma is a condition reserved for the almost frequently and harmless kind of disorder known as Langerhans cells histiocytosis. Eosinophilic granuloma is a harmless disorder that affects children and inexperienced adults, especially males.
The solitary bone lesion may be asymptomatic, or it may cause bone pain because of expansion of the medullary bone. Eosinophilic granuloma is found in the skull, mandible, spine and long bones. The male to female ratio is two to one. The extra immune cells may form tumors, which can affect various parts of the body. In children, eosinophilic granuloma X usually involves the bones, and may affect one or more sites. The skull is frequently affected. Somewhere around three fourths of people that develop eosinophilic graunuloma will have histiocytosis X.
Eosinophilic granuloma is characterized by an unmarried or dual bony lesions, and it predominantly affects children, adolescents, or inexperienced adults. Solitary lesions are more popular than dual lesions. Any ivory can be involved, but the almost popular sites include the skull, mandible, backbone, ribs, and lengthy bones. Symptoms include localized pain, tenderness, swelling, fever, and leukocytosis. Eosinophilic granuloma, which is classified with tumors of histiocytic origin, may be an isolated bony lesion or parenchymal, or may be part of systemic disease. In eosinophilic granuloma, the disease stabilizes or improves in about one-half of the affected people and the other half progress to a permanent loss of lung function. Quitting smoking can improve the outcome in people whose lungs are affected with histiocytosis. No prevention is known for the childhood forms of the disease.
The differential diagnosis includes osteomyelitis, non hodgkin's lymphoma, and hodgkin's disease. Most patients have no symptoms, and the diagnosis is normally based on radiographic show of a harmful ivory lesion arising from the marrow cavity and on distinctive morphologic findings. This disorder is treated with corticosteroids, which suppress immune function. Smoking may worsen the response to treatment and should be stopped. Radiation therapy or limited surgery may also be used to treat bone lesions. Treatment may include antibiotics, breathing assistance with a respirator, physical therapy, selenium-based shampoo for scalp problems, and hormone replacement to deal with hormonal dysfunction.
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