Diazepam (Valium) -A Classic in Neuroscience

Diazepam is one of the most successful drugs from the beginning of the psychopharmacological revolution that was initiated in 1950. It is used for treating a wide range of central nervous system disorders like epilepsy, anxiety, etc. The FDA-approved drug is also used for sedation purposes in ICU and for the treatment of children, suffering from Cerebral Palsy (Off Label). Diazepam can be rightly called a "Classic in Neuroscience". You can buy valium 5mg online through online pharmacies easily but only on a prescription.

Mechanism of Action 

Diazepam works by augmenting one activity of GABA, binding to a unique site on the alpha-gamma subunit interface. The interaction of Diazepam with these sites enhances the neuronal chloride ion influx on the GABA binding leading to hyperpolarized postsynaptic membranes. 

These actions are commonly observed in the thalamus, hypothalamus, cerebral cortex, limbic system, thereby, producing a very calming effect on the neuronal processes in these areas. This results in antiepileptic and anxiolytic effects. The other reasons behind the huge commercial success of diazepam are its targeted mechanism, potency, and high bioavailability. Its fast action has also made it one of the most popular benzodiazepines. 

Manufacturing Information of Diazepam

Originally manufactured by Hoffman La Roche as Valium, Diazepam is the generic name of this medicine. It was first synthesized in 1959, but it entered the US market in 1963 and immediately took the market by storm in the years 1968 to 1982. Soon after the patent expired in 1985, 500 different brands of diazepam are now available in the market in the form of tablets, suspensions, gels, suppositories, and other formulations. 

Administration 

As mentioned above, Diazepam comes in various forms and that is why the administration of the drug varies. 

• For the treatment of alcohol withdrawal, the initial dose starts from 10 mg IV. The oral dose also starts from 10 mg. You can easily find diazepam 10mg for sale in online pharmacies, and avail attractive discounts on them. 
• For anxiety, 2 to 10 mg dose is given orally twice a day or 4 times a day depending on the symptoms.
• A 2 to 10 mg dose is given for muscle spasms too.
• A 5 to 10 mg loading dose is given during sedation in ICU. 
• For the treatment of seizures, a 2 to 10 mg dose is given orally twice or four times a day.

Use of Diazepam in special populations

• Pregnant Patients: Diazepam crosses the placental barrier, and that is why a baby may also suffer from withdrawal symptoms of diazepam soon after birth. These withdrawal symptoms may continue from a few days to a few weeks. It is advised that pregnant women should consult their doctors thoroughly before using diazepam during pregnancy.
• Breastfeeding women: Diazepam can enter the mother’s milk and hence can affect the nursing baby. Since diazepam has a long half-life, its metabolites may enter the infant. For this particular reason an infant, whose mother is on diazepam, should be monitored regularly for lethargy and drowsiness.
• Elderly: Since elderly people have decreased renal function, they are unable to clear out diazepam, and hence the medicine should be given to them very carefully. For elderly people, the minimum dosage is fixed, and it should not exceed.

Monitoring

It is crucial to look out for the side effects while on diazepam. It is possible to suffer from depression, confusion, urinary retention. Nausea, constipation, respiratory depression, seizures, etc. some people may also suffer from dependency and abuse. Regular monitoring is recommended while being on Diazepam. Also in case, you wish to stop the intake of the drug, go for lower doses.

Conclusion

Diazepam is on the market for about 50 years and is one of the most successful drugs produced by the pharmaceutical industry. It has no doubt revolutionized the treatments in epilepsy and anxiety, and that is why it truly deserves to be called a classic in neuroscience. It has opened the door to modern medicine and is still considered the first-line treatment for anxiety disorders. If you are also suffering from anxiety, panic disorder, or GAD, diazepam can help you. Buy diazepam online, and put an end to your suffering. Rest assured of exceptionally great results with this magical drug. 

ALSO READ: VALIUM MEDICINE: THE BEST SOLUTION FOR SEIZURES OR PANIC ATTACKS

----> https://easymedsusa.weebly.com/blog/valium-medicine-the-best-solution-for-seizures-or-panic-attacks

ALSO READ: The Best You Can Get to Treat your Anxiety And Panic Attacks – Diazepam

----> https://www.easymedsusa.com/the-best-you-can-get-to-treat-your-anxiety-and-panic-attacks-diazepam/