Clinically observation of minoxidil in hair loss treatment

It also re-expands the hair follicles, extend the newborn period and stimulate the regeneration of hair at the same time. It does not affect the body's hormones. Hair regrowth required the time for 8-16 weeks and its effect is obvious.

Cosmetic raw material minoxidil makes the miniaturization of hair follicle increased. According to experimental studies, in the hair follicles in vitro, by adding minoxidil increase the cultivation of the hair follicle growth time. The hair follicles of hepatocyte growth factor and vascular endothelial growth factor are the dermal papilla of the two major growth factor, an important role in the regulation of hair growth cycle. Minoxidil can increase dermal papilla cells of vascular endothelial growth factor expression. Therefore considered that minoxidil through the above cytokines to stimulate the growth of hair follicles and dermal papilla blood vessel formation and function, which plays an important role in the treatment of hair loss.

In 1988, 2 percent minoxidil solution was approved topical treatment of male pattern androgenetic alopecia. 8-50 year-old male patients with mild to moderate top of the hair loss, minoxidil group number of hairs increased after 12 months of treatment, histological proof of the diameter of the hair growth by minoxidil group also increased. Applied 5% minoxidil in male pattern androgenetic alopecia, 2% Minoxidil, Seoul and placebo-controlled, by 48 months of treatment, the results of the application of 5% minoxidil group hair count than the 2% minoxidil was 45%, five times higher than in the placebo group.

5% minoxidil solution can be used as male pattern hair loss. 2%, 5% minoxidil, placebo and no treatment group, double-blind, controlled study, observed a total of 96 weeks, either 2% or 5% minoxidil topical in the effectiveness of the promotion of hair growth and increase hair higher than the placebo and treatment group, the efficacy of more than 2 to 3 months after treatment, but were followed up for 4 weeks after discontinuation of 96 weeks, they began to hair loss, this result show minoxidil can promote hair growth. In early stage of minoxidil topical treatment, it promotes hair growth in the number of miniaturized surge in these hair follicles are still in short growth cycle, so the application of minoxidil topical treatment of patients often complained of in the treatment of 12 weeks, hair loss temporary increase.

Minoxidil solution is only used to promote hair growth topical drugs women androgenetic alopecia patients. In women, application of 2% solution. Observed under a 32-week efficacy of minoxidil treatment groups, hair growth, weight increased by 42.5%. 2% solution with 5% solution efficacy, randomized, double-blind controlled study after 32 weeks and 48 weeks of observation, the results of 5% solution is not better than the 2% solution of efficacy in female androgenetic alopecia.

In female androgenetic alopecia, they can buy minoxidil solution. It has similar side effects. But the hair histiocytosis is more commonly than men. Its incidence is about 2-5%. The hair histiocytosis can occur in the eyebrow, zygomatic, buccal, occasionally in the lip and chin. Hair histiocytosis will be reduce or dissipate a year later. One to six months after stopping taking drug, the situation is completely subsided. Occurrence of hair histiocytosis is not entirely clear. It may relate to the following reasons: rich blood vessels of scalp and liquid local vascular proliferation.

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