Since China began large-scale use of retinoic acid to prevent esophageal cancer in higher esophageal cancer incidence regions and achieved good results in 1983, the world began to study about whether retinoic acid can prevent or treat other tumors too.
Retinoic acid for the treatment of cutaneous squamous cell carcinoma in addition to clinical effect in the prevention of cutaneous squamous cell carcinoma occurred also have a certain effect, but applied to the clinical treatment of human use of a single retinoic acid treatment of squamous cell carcinoma and not necessarily with special effects. In the first phase of clinical trials, nine cis-retinoic acid, confirmed the role of the lung, breast, colorectal, head and neck cancer, skin cancer or ovarian cancer do not have a single retinoic acid treatment; but an 13 cis- Phase II Clinical Trial of tretinoin and alpha-interferon, and found that this treatment response rate of 68% squamous cell carcinoma of the skin, in this way as the adjuvant treatment of head and neck cancer have a certain effect.
In fact, the early use of retinoic acid to treat acne and oral leukoplakia with good results since most of the experiments and clinical trials are designed with lesions with the characteristics of the squamous cell. Human oral cancer cells implanted in nude mice was found nine cis-retinoic acid can enhance the effect of cisplatin treatment, clinical, such an integrated approach on the head and neck cancer also have the effect of addition of the current problem is that these sporadic experiments or results of clinical trials was not reproducible, and some even contradictory, the main reason for this contradiction differences may be as stimulating cell growth and promote the cycle of cell differentiation mechanism of these two cell physiology may vary due to cell, can not be summarized. Therefore, cosmetics material retinoic acid may have different reactions in treatment of specific cells.
At present, the main limitation of the retinoic acid treatment is that the side effects it produces, such as dry mouth and abnormal liver function. Although it is not a big problem, it will reduce the willingness of patients to receive treatment. For retinoic acid treatment-related side effects, in fact it is about the different performances of the different tissues and different retinoic acid receptor. Therefore, the most recent strategy is for tissue-specific performance and synthesis only a certain kind of retinoic acid receptor specific drugs. According to this strategy, recently some new products have entered the first phase and second phase of clinical trials. And soon we will see the same effective retinoic acid products like the one curing acute promyelocytic leukemia in markets.Source:http://www.cosprm.com
The application of tungsten in various industries
Steel Industry Most of tungsten applied in the production of special steels. The widely used high-speed steel was containing 9-24% of tungsten, 3.8-4.6% of chromium, 1-5% of vanadium, 4-7% of cobalt, 0.7-1.5% of carbon.
Magic effects of coconut oil
According to records, coconut oil can be regarded as the nobility of skin care plant extracts. It was rich in exotic tension of tropical plants, which can enhance the contractile force of the pores, perfectly beautify and nourish the skin.
The Evolution and Impact of Abamectin and Emamectin Benzoate in Pest Control
Abamectin and its derivative, emamectin benzoate, have emerged as pivotal substances in the realm of pest control, offering a broad-spectrum efficacy against various pests while maintaining a favorable environmental profile. As the agricultural industry continues to evolve, these compounds have adapted to meet the growing challenges of pest resistance, expanding their market applications and maintaining cost-effectiveness despite rising production costs.
