The researchers reported an anti-tumor passage present in the mouse and human body, the passage including a special fatty acid molecule of the secretion of a neural progenitor cell (NPC) - capsaicin.
NPC is a kind of cells present in children's brain, can be used to fight tumors, can secrete substances induced cancer cell death.
The scientists determined these secrete substances is capsaicin, and clarify the mechanism of capsaicin protects the brain from the tumor against. The capsaicin signaled by the capsaicin receptor TRPV1, TRPV1 is highly expressed in malignant glioma brain cancer, capsaicin discrete sampling and activate the cancer cells in a strengthen pathways to promote cancer cell death, however, in the no tumor brain, the level of TRPV1 expression is low. Capsaicin is the active ingredient in chili, have irritating and burning sensation in the oral cavity of mammal. Capsaicin and some compounds associated and referred to as peppers, they are secondary metabolites produced by the pepper, pure capsaicin is a water-repellent lipophilic, colorless, odorless, crystalline or waxy compound.
Capsaicin in the treatment of adult mouse brain tumor, can reflect this young NPC’s tumor inhibition. Grown in intracranial tumors are known as brain tumors, including primary brain tumor from the brain parenchyma and transferred from other parts of the body to the brain secondary brain tumor. In recent years, the incidence of intracranial tumors show upward trend. According to statistics, the intracranial tumor accounts for about 5% of the whole-body tumor, accounting for 70% of childhood tumors, and other malignancies ultimately will be 20-30% turn into the intracranial.
The study reveals a potentially powerful use of endogenous tumor of the brain molecules inhibit, the inhibition dependent on a large number of NPC, or have significance for the treatment of patients in different age. In addition, the discovery of the capsaicin receptor TRPV1 passed signal can be as a candidate drug target pathway for brain tumors. About the tumor suppressor role of capsaicin has long been understood by scientists, and tireless research on the mechanism. In 2007, British researchers suggested that the key mechanism of capsaicin tumor suppressor is attacking the mitochondria of cancer cells.
Mitochondria is the energy factories of cells, capsaicin attacks the mitochondria of cancer cells cause the cancer cells to apoptosis. Researchers object to cultured cells of lung cancer, and pancreatic cancer, found that capsaicin attack tumor cells without harming healthy cells. This is because there is a great difference of the mitochondrial biochemical characteristics of the tumor cells and normal cells.
According to capsaicin supplier, capsaicin is very easy to get in the daily diet, so the results of this study seems to demonstrate eating such as chili foods is not only safe, but also have the effect of preventing cancer. In addition, capsaicin has been used as pharmaceutical raw materials of drugs in treating psoriasis and other skin disease, the scientists hope that through further research and demonstration, capsaicin can be developed into anticancer drugs.
Source:http://www.cospcn.com
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