Can minoxidil be added into shampoos?

Minoxidil can direct relax vascular smooth muscle. There is a strong expansion of the role of small arteries and peripheral resistance decreased, the blood vessels to dilate, blood pressure, had no effect on the capacitance vessels, it can promote venous return. At the same time, due to the reflex regulation and positive frequency effect, cardiac output and heart rate can increase, but does not cause orthostatic hypotension. At present, minoxidil is a clinical second or third line blood pressure-lowering medicine. It can be used for the treatment of refractory hypertension and renal hypertension.

Minoxidil is a drug and naturally there are adverse drug reactions. The main side effects of oral minoxidil: reflex sympathetic excitement caused palpitations and arrhythmia, hirsutism. The main side effects of topical formulations skin irritation, medication site dermatitis, erythema, itching and other reactions. Although the uptake in the topical formulations are very small, but can not rule out an impact on heart disease patients with a history of the disease. Suffering from cerebrovascular disease, and non-hypertension-induced heart failure, coronary heart disease, angina pectoris, myocardial infarction, pericardial effusion, renal dysfunction and other diseases, must be careful in minoxidil allergy persons and pheochromocytoma patients to be disabled.

In the hair follicles in vitro, by adding minoxidil can increase the cultivation time of growth of hair follicles. The hair follicle hepatocyte growth factor and vascular endothelial cell growth factor is the dermal papilla of the two major growth factor, an important role in the regulation of hair growth cycle. The present study suggests that minoxidil can directly stimulate the proliferation and differentiation of hair follicle epithelial cells, promote angiogenesis and increase local blood flow.

At present, there are sufficient clinical trials confirmed that minoxidil for androgenetic alopecia, alopecia areata has a good effect, but requires long-term medication to maintain efficacy. The shorter the hair loss, the smaller the area, the better the prognosis. High concentrations of the efficacy of low concentrations of large-scale clinical trials have confirmed that topical minoxidil hair loss treatment is safe.

The major adverse event of minoxidil solution is hirsutism. In clinical use of minoxidil, cosmetic raw material suppliers find that patients have varying degrees of hirsutism. In addition, minoxidil solution may cause irritation or allergic contact allergic reactions. Some patients have the symptoms of itching and scalp desquamation. But patch tests in patients with allergic contact dermatitis show that, for most patients, the propylene glycol solvent is true allergens rather than minoxidil itself. So replacement of solvents should prevent some allergic reactions. It is worth mentioning that minoxidil is approved in indications for androgenic alopecia (also known as male pattern hair loss) and alopecia areata. Consumers should also consult the dermatologist before buying. They should ask about using details from physician or pharmacists.

Source:http://www.cosprm.com