Superoxide Dismutase

Feb 23
08:23

2012

David Yvon

David Yvon

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SOD belongs to enzymes. Its nature not only depends on the protein part but also the active site metal ions. In accordance with the different types of combination of metal ions, SOD can be divided into CuZn-SOD, Fe-SOD and Mn-of SOD. 3 kinds of enzymes all can catalyze 0 disproportionation to H202 and O2. Cosmetics mostly use the CuZn-SOD or Mn-SOD.

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SOD exists in animals,Superoxide Dismutase Articles plants, algae and other prokaryotes body (such as cattle and human erythrocytes), extraction and purification of enzymes from different sources astaxanthin, its amino acid sequence or composition is still some difference, and thus the nature of the enzyme is not exactly the same. CuZn-SOD enzyme activity depends not only on the enzyme protein, but also with Cu2 and zn2. General experimental conditions, the enzyme protein is quite stable, without destruction of acetic acid and chloroform, less susceptible to hydrolysis at 37 ° C, PH 7.0,0.05 mol / L potassium phosphate buffer, SOD activity to maintain more than three weeks, circular dichroism as indicators to determine the enzyme with or without changes, 4% sodium dodecyl sulfate had no effect on the activity of SOD activity of CuZn cyanide, H2, 02 allows it to inactivation or inhibition of the enzyme activity. The use of SOD should pay particular attention to tretinoin compatibility, PH and temperature of the medium, and today can be made into liposomes or microcapsules to increase its stability.

According to the free radical theory of aging process of skin aging, free radical damage to the skin is an important factor. The body produces free radicals and fatty acids role in the generation of malondialdehyde and other substances, and their role in the formation of cell membrane protein lipofuscin deposition in the skin, for a variety of stain. The free radicals also can make the collagen fibers within the epidermis, crosslinking and degeneration of elastic fibers become brittle and loses its elasticity. When lack of moisture of the skin, easy to make elastic fibers to fracture the formation of wrinkles, the role of free radical damage to the skin is great if they can take measures to reduce skin formation of free radicals, effectively eliminate the free radicals generated, and can keep the skin moisture, can effectively slow down the aging of the skin.

SOD is an effective scavenger for superoxide anion radicals. It has been applied in cosmetics material. But the effect is not particularly significant because SOD is easy to lose the deactivation. For this point, there is a new type of cosmetics containing SOD hyaluronic acid and 200 to 400 UV absorption in the market. It can significantly slow the skin aging.Source:http://www.cosprm.com